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Age-Related Stiffness

Meaning

The physiological reduction in flexibility and elasticity of connective tissues, primarily collagen and elastin, that occurs as a natural consequence of chronological aging. This systemic decline impacts joint range of motion and arterial compliance, contributing to reduced physical performance and increased cardiovascular risk over time. Clinically, it is a key marker of biological age that reflects the progressive accumulation of advanced glycation end products (AGEs) and structural protein cross-linking. Understanding this stiffness is vital for developing targeted longevity interventions.