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Age-Related Signaling Decay

Meaning

Age-Related Signaling Decay is the biological process defined by the gradual decline in the efficiency and fidelity of intercellular and intracellular communication pathways over time. This decay impacts critical physiological processes such as hormone receptor binding, second messenger generation, and gene transcription responsiveness. It represents a fundamental aspect of cellular senescence, affecting the body’s ability to maintain homeostasis and respond effectively to external stimuli. Clinically, this diminished signaling capacity underlies the reduced efficacy of endogenous hormones and pharmacological agents in older individuals.