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Age-Related Signal Drift

Meaning

This term describes the progressive, subtle degradation in the fidelity and synchronization of the body’s internal communication systems, particularly the endocrine and neuroendocrine axes, as an individual ages. The phenomenon involves a gradual blunting of receptor sensitivity and a desynchronization of pulsatile hormone release patterns, moving away from youthful optimal states. Clinically, this drift manifests as reduced systemic responsiveness to hormonal cues, contributing to the typical decline in physiological function associated with senescence.