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Age-Related Shifts

Meaning

Age-Related Shifts are the predictable, progressive alterations in physiological function and homeostatic regulation that occur across the human lifespan. In endocrinology, this specifically describes the measurable decline in the production, sensitivity, and pulsatility of key hormones, such as somatopause (GH decline) and andropause/menopause (sex steroid decline). Understanding these systemic shifts is central to proactive health management and the implementation of effective longevity protocols. These changes represent a deviation from the optimal youthful set points.