What is the Origin of Age-Related Physiological Changes?

The term derives directly from human physiology and the field of biogerontology, describing the universal processes of senescence. It recognizes the inherent limitations of biological systems and the cumulative effect of molecular damage over a lifespan. The concept serves as a baseline for distinguishing normal aging from pathological disease states.

What is the Mechanism of Age-Related Physiological Changes?

Mechanistically, these changes are driven by factors like telomere shortening, mitochondrial dysfunction, accumulation of cellular debris, and a decline in hormonal output, such as the age-related reduction in DHEA and growth hormone. The hypothalamus-pituitary-adrenal axis often exhibits altered sensitivity, contributing to systemic dysregulation. These fundamental cellular and molecular changes underpin the macroscopic functional decline observed clinically.

Age-Related Physiological Changes

Meaning

These represent the inevitable, non-pathological alterations in biological function that occur progressively over time in all human systems. Such changes include a gradual decline in tissue elasticity, reduced organ reserve capacity, and subtle shifts in neuroendocrine feedback loops. They are distinct from overt disease but increase vulnerability to clinical conditions.

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Age-Related Physiological Changes

Meaning

Origin

Mechanism

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