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Age-Related Physical Atrophy

Meaning

Age-related physical atrophy denotes the progressive and involuntary loss of lean body mass, specifically skeletal muscle and bone density, which occurs with advancing age, clinically known as sarcopenia and osteopenia/osteoporosis. This condition represents a significant deterioration in physical structure and function, directly impairing strength, mobility, and overall functional independence. It is a critical geriatric syndrome that dramatically impacts quality of life and increases the risk of falls and fractures. The reduction in muscle protein synthesis and increased catabolism contribute to this systemic degradation of physical tissue integrity.