The measurable, progressive decline in physical, cognitive, and metabolic capabilities observed in individuals as they advance in age. This decrement encompasses reductions in muscle strength, cardiovascular efficiency, reaction time, and overall metabolic rate. It is a multifactorial consequence of cellular senescence and systemic physiological decline that impacts daily function.
Origin
This concept is rooted in sports science, exercise physiology, and gerontology, where researchers quantitatively track the reduction in maximum functional capacity across different age cohorts. The term directly links the passage of time, or age-related changes, to a measurable decline in function, known as performance decrement. It forms the basis for anti-aging and vitality interventions.
Mechanism
The primary drivers include sarcopenia, characterized by the loss of muscle mass and quality, decreased mitochondrial function leading to reduced ATP production, and diminished hormonal signaling, such as lower growth hormone and testosterone levels. Additionally, cumulative oxidative stress and chronic low-grade inflammation impair tissue repair and functional integrity. These factors collectively reduce the physiological reserve capacity.
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