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Age-Related Pathophysiology

Meaning

Age-related pathophysiology describes the functional changes that occur in organs and systems over time, which ultimately lead to disease and decline in physiological reserve. It encompasses the underlying biological processes that transition from normal aging to a diseased state, such as chronic inflammation, immune dysfunction, and hormonal imbalances. This shift is characterized by a gradual erosion of homeostatic capacity, making the individual increasingly vulnerable to stressors. Clinically, understanding this pathophysiology is essential for differentiating between normal aging effects and treatable disease states.