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Age-Related Neurological Disorders

Meaning

A category of progressive conditions characterized by the deterioration of central and peripheral nervous system function, with incidence increasing significantly as a function of chronological aging. These disorders involve the gradual loss of neuronal structure and function, leading to cognitive decline, motor impairment, and disruption of neuroendocrine signaling. Hormonal fluctuations associated with aging, such as declining sex steroids and neurosteroids, are increasingly recognized as significant contributing factors to their pathophysiology.