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Age-Related Neural Attrition

Meaning

Age-Related Neural Attrition describes the progressive, non-pathological loss of structural and functional integrity within the central nervous system that occurs naturally over the human lifespan. This process encompasses a gradual reduction in neuronal density, synaptic connections, and white matter volume, contributing to measurable, albeit typically subtle, declines in certain cognitive functions. From an endocrinological perspective, the decline in neurosteroids is considered a major contributing factor to this structural regression.