What is the Origin of Age-Related Morbidity Delay?

The concept is a central tenet of geroscience and longevity medicine, evolving from the demographic observation that while lifespan has increased, the period of morbidity has also lengthened. It is directly related to the "compression of morbidity" hypothesis first proposed in the early 1980s. Clinically, it acknowledges that aging is the primary risk factor for numerous chronic conditions, making its deceleration a key therapeutic target.

What is the Mechanism of Age-Related Morbidity Delay?

Delaying morbidity involves systemic intervention targeting the hallmarks of aging, such as cellular senescence, mitochondrial dysfunction, and chronic inflammation. Optimizing endocrine signaling, particularly insulin sensitivity and growth factor pathways, plays a crucial role in maintaining tissue repair and metabolic homeostasis. Successful implementation requires comprehensive management of physiological reserves to resist pathological insults and maintain organ system integrity.

Age-Related Morbidity Delay

Meaning

Age-Related Morbidity Delay is the clinical objective of postponing the onset and accumulation of chronic, age-associated diseases, thereby compressing the period of illness at the end of life. This represents a significant extension of the healthspan, rather than merely extending lifespan alone. The goal is to ensure that a greater proportion of an individual’s life is spent in a state of high functional capacity and minimal disease burden.