What is the Origin of Age-Related Metabolic Drift?

This nomenclature arises from metabolic research observing cohort changes over decades, noting deviations from youthful metabolic norms even in ostensibly healthy older adults. The term 'drift' suggests a slow, continuous process rather than an abrupt pathological event. It bridges geriatric medicine with fundamental principles of bioenergetics.

What is the Mechanism of Age-Related Metabolic Drift?

The process involves complex interactions between declining anabolic signaling, chronic low-grade inflammation (inflammaging), and altered mitochondrial function within muscle and adipose tissues. Reduced physical activity further exacerbates the shift away from glucose utilization towards reliance on fat oxidation pathways, leading to lipotoxicity risks. Ultimately, this drift impairs cellular efficiency in energy transduction.

Age-Related Metabolic Drift ∞ Area

Age-Related Metabolic Drift

Meaning

Age-Related Metabolic Drift refers to the gradual, often insidious shift in whole-body energy partitioning and substrate utilization that occurs with advancing age, independent of acute illness. This drift frequently manifests as increased visceral adiposity, decreased insulin sensitivity, and altered basal metabolic rate (BMR). Recognizing this drift is crucial for proactive longevity management.