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Age-Related Inflammation

Meaning

Age-Related Inflammation, or “inflammaging,” is the chronic, low-grade, systemic inflammatory state that progressively increases with chronological age. This pervasive condition is characterized by persistently elevated circulating levels of pro-inflammatory cytokines such as Interleukin-6 and Tumor Necrosis Factor-alpha. It is a sterile, non-infectious inflammation recognized as a fundamental, non-pathological driver of immunosenescence and a significant contributor to numerous age-associated chronic diseases. The continuous low-level inflammatory signal disrupts endocrine and metabolic homeostasis, accelerating biological decline.