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Age-Related Hormone Decline Pathophysiology

Meaning

The underlying biological mechanisms that lead to a progressive reduction in the synthesis, secretion, or efficacy of key endocrine signaling molecules as an organism advances in chronological age. This involves specific changes within the hypothalamic-pituitary-gonadal (HPG) or hypothalamic-pituitary-adrenal (HPA) axes, leading to functional deficits. Clinically, this decline is associated with sarcopenia, altered body composition, and diminished vigor. Understanding this pathophysiology is foundational to targeted anti-aging and optimization strategies.