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Age-Related Hormonal Descent

Meaning

The progressive, quantifiable reduction in circulating levels of critical anabolic and regulatory hormones, such as testosterone, DHEA, and growth hormone, observed across the lifespan. This descent is a key physiological hallmark of aging, distinct from acute pathology. Understanding this trend is fundamental to assessing an individual’s endocrine reserve. We observe changes in both total and free fractions of these vital messengers. This pattern often correlates with shifts in body composition and energy status.