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Age Related Hormonal Decay

Meaning

The progressive, physiological decline in the production, bioavailability, and receptor sensitivity of various endocrine hormones that occurs naturally with chronological aging. This systemic reduction affects critical hormones such as testosterone, estrogen, progesterone, dehydroepiandrosterone (DHEA), and growth hormone. The decay contributes directly to a spectrum of age-related clinical manifestations, including sarcopenia, reduced bone mineral density, diminished cognitive function, and altered metabolic homeostasis. Clinical practice often refers to this phenomenon as endocrinosenescence, highlighting the inevitable involution of glandular function over time.