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Age-Related Genetic Decline

Meaning

Age-Related Genetic Decline describes the progressive accumulation of genomic and epigenomic alterations that compromise cellular function and regulatory fidelity as an organism ages. It encompasses phenomena like telomere shortening, increased somatic mutations, and dysregulation of gene expression profiles, collectively driving the physiological manifestations of senescence. In the context of hormonal health, this decline directly impacts the responsiveness and output of endocrine glands, contributing to conditions like andropause and menopause. The integrity of the genome is paramount for sustaining optimal physiological function.