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Age-Related Frailty

Meaning

Age-Related Frailty is a distinct clinical syndrome characterized by a profound decrease in physiological reserve and diminished resistance to various stressors, stemming from cumulative, multi-systemic decline. This state of increased vulnerability significantly elevates an individual’s risk for adverse health outcomes, including acute illness, disability, falls, and hospitalization, representing a critical challenge to healthy longevity. Importantly, frailty is understood not as an inevitable consequence of chronological age but rather as a state of pathological physiological decline that can be clinically addressed.