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Age-Related Endocrine Declines

Meaning

Age-related endocrine declines refer to the progressive, physiological reduction in the production, secretion, and tissue responsiveness of numerous hormones that occurs as a natural part of the human aging process. This generalized hormonal attenuation affects multiple axes, including the somatotropic, gonadal, and adrenal systems, fundamentally altering homeostasis and contributing to many senescence-associated phenotypes. These declines are not always pathological but represent a measurable shift from youthful hormonal profiles to those characteristic of advanced age.