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Age Related Dysfunction

Meaning

The progressive decline in physiological function and homeostatic capacity that occurs as an organism ages, leading to increased vulnerability to disease and mortality. This intrinsic biological process reflects the cumulative impact of molecular and cellular damage over time, affecting multiple organ systems including the endocrine axis. Clinical manifestations often involve hormonal imbalances, reduced metabolic efficiency, and impaired tissue repair mechanisms, significantly contributing to the overall burden of senescence.