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Age-Related Downregulation

Meaning

Age-Related Downregulation describes the progressive and predictable decline in the expression or sensitivity of specific cellular receptors, enzymes, or hormonal production pathways over time. This biological phenomenon is a fundamental component of the aging process, leading to diminished functional reserve and impaired homeostatic capacity. Clinically, this downregulation is observed as reduced levels of growth hormone, testosterone, or decreased tissue responsiveness to insulin and thyroid hormones. Understanding this process is essential for developing longevity and wellness protocols.