Age-Related Diseases refer clinically to the spectrum of chronic pathologies that increase in prevalence with advancing chronological age, often involving systemic inflammation and cumulative cellular damage.
Origin
The term ‘Age-Related’ derives from the concept of senescence, where biological processes inherently decline over time, leading to reduced physiological reserve and increased susceptibility to illness.
Mechanism
These conditions frequently manifest through dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, altered sex steroid feedback loops, and impaired cellular signaling cascades affecting tissue repair and homeostasis.
The commercialization of senolytics is challenged by the need to fit a therapy targeting the aging process into a medical system designed to treat specific diseases.
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