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Age-Related Disease

Meaning

These are clinical conditions where advancing chronological age is the primary, non-modifiable risk factor for onset and progression. They represent a decline in physiological function and homeostatic capacity, often manifesting as chronic illnesses that significantly impact longevity and quality of life. Common examples include neurodegenerative disorders, cardiovascular disease, and type 2 diabetes, all linked to systemic changes in hormonal and metabolic signaling pathways. Understanding these diseases is crucial for developing interventions that promote healthspan alongside lifespan.