Age-Related Deterioration clinically refers to the progressive, inevitable decline in physiological function and structural integrity across various organ systems that occurs over time. This process is marked by a reduction in homeostatic reserve, making the organism more susceptible to stress, disease, and ultimately, mortality. In the context of hormonal health, it often manifests as diminished endocrine gland output and reduced tissue sensitivity to key hormones. Addressing this fundamental biological process is central to longevity and wellness protocols.
Origin
The term is rooted in gerontology and human physiology, describing the natural biological phenomena of senescence and aging. Etymologically, ‘age’ refers to the duration of existence, while ‘deterioration’ derives from the Latin deterior, meaning “worse,” signifying a worsening of condition. In clinical practice, this decline is quantified by measuring biomarkers like telomere length, cellular senescence markers, and age-related hormone declines.
Mechanism
The deterioration is driven by a complex interplay of cellular and molecular mechanisms, including accumulated DNA damage, mitochondrial dysfunction, chronic low-grade inflammation (inflammaging), and impaired cellular repair pathways. Specifically, hormonal changes, such as the decline in growth hormone, DHEA, and sex steroids, directly contribute to the loss of muscle mass, bone density, and cognitive function. These interconnected processes accelerate the loss of functional capacity throughout the body.
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