The proactive clinical and lifestyle pursuit of mitigating or reversing the typical physiological and functional deterioration associated with advancing chronological age. This concept centers on maintaining peak biological function rather than merely managing age-related disease states. It involves comprehensive interventions targeting the hallmarks of aging at a cellular and systemic level.
Origin
This term arises from the convergence of modern endocrinology, gerontology, and personalized wellness, moving beyond traditional palliative care models. Its foundation lies in the understanding that aging is a modifiable biological process, not an immutable fate. The philosophical root is a shift from accepting decline to aggressively optimizing human longevity and healthspan.
Mechanism
Rejection of age-related decline is achieved through strategic modulation of endocrine pathways, including optimizing hormones like testosterone, estrogen, and growth hormone. The mechanism involves enhancing cellular repair processes, reducing chronic inflammation, and supporting mitochondrial function. These interventions aim to restore youthful homeostatic balance and improve tissue resilience against cumulative damage.
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