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Age-Related Complexity Loss

Meaning

Age-Related Complexity Loss describes the progressive reduction in the intricate, non-linear variability characteristic of a healthy, adaptive physiological system. This phenomenon is observed across multiple biological scales, encompassing hormonal pulsatility, heart rate variability, and neural network signaling patterns. Loss of complexity is generally associated with an impaired capacity for the organism to respond effectively to internal and external stressors, signaling a decline in overall resilience. Clinically, this reduction indicates a shift from dynamic, robust homeostasis toward a more rigid, predictable, and ultimately fragile state. Restoring this complexity is a core objective in promoting healthspan and longevity.