The observable, gradual alteration in executive function, memory processing speed, and neuroplasticity associated with chronological aging. This shift reflects underlying physiological changes within the central nervous system and its supporting endocrine milieu. We observe changes in synaptic efficiency that affect higher-order thinking capabilities.
Origin
This terminology arises from longitudinal studies in gerontology and neuropsychology, charting normative decline trajectories. Etymologically, ‘shift’ implies a directional movement away from peak performance established in earlier life stages. In the context of hormonal health, it is often linked to the decline of specific trophic factors and sex steroids.
Mechanism
The mechanism often involves reduced neurotrophic factor support, such as BDNF, coupled with age-related oxidative stress accumulation in neuronal tissues. Alterations in thyroid hormone sensitivity within the brain contribute significantly to processing delays. Furthermore, chronic low-grade inflammation can disrupt the blood-brain barrier integrity, subtly impairing optimal cognitive throughput.
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