A clinical objective focused on employing strategies to slow, halt, or partially reverse the progressive impairment of cognitive functions associated with advancing chronological age. This addresses domains such as executive function, memory consolidation, and processing speed. Mitigation aims to preserve neuroplasticity and neuronal integrity over the lifespan.
Origin
This concept originates from the intersection of gerontology and neurobiology, specifically examining age-associated changes in brain structure and function. The term “mitigation” implies an active reduction in the severity or impact of the decline, rather than simple acceptance of senescence. It is rooted in understanding age-related endocrine shifts that affect central nervous system health.
Mechanism
Mitigation often targets systemic factors that influence brain health, including chronic inflammation, oxidative stress, and impaired cerebral blood flow. Optimizing neurotrophic factors, such as BDNF, through lifestyle or targeted supplementation is a key mechanism. Furthermore, balancing sex hormones and thyroid function can directly support neuronal membrane health and synaptic efficiency, counteracting age-related decline trajectories.
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