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Age-Related Androgen Depletion

Meaning

Age-Related Androgen Depletion is the gradual, physiological decline in the production and bioavailability of androgen hormones, primarily testosterone, that occurs naturally with advancing chronological age in both males and females. This reduction is often clinically linked to diminished gonadal function and altered feedback loops within the hypothalamic-pituitary-gonadal (HPG) axis. It is a recognized component of the aging process that can significantly impact muscle mass, bone density, mood, and overall vitality.