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Age of Initiation Threshold

Meaning

The Age of Initiation Threshold is the specific chronological or biological age at which a proactive intervention, such as hormonal optimization, is clinically determined to provide the maximum therapeutic benefit with the lowest risk profile. This threshold is highly individualized, reflecting a critical balance between the degree of age-related physiological decline and the remaining responsiveness of target tissues. Clinicians use a convergence of symptom assessment, detailed biomarker analysis, and genetic factors to pinpoint this optimal starting point for intervention. Recognizing this pivotal moment is essential for optimizing long-term hormonal health and promoting genuine longevity.