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Age-Induced Neuronal Stress

Meaning

A chronic state of cellular strain within the central nervous system characterized by accumulated molecular damage and compromised homeostatic mechanisms, primarily driven by the biological aging process. This physiological stress involves heightened oxidative burden, mitochondrial dysfunction, and the accumulation of misfolded proteins, which collectively impair neuronal function and communication. It represents the measurable deterioration of the neuronal microenvironment that precedes overt neurodegenerative pathology.