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Age-Dependent Signaling Decline

Meaning

Age-Dependent Signaling Decline describes the progressive, inevitable reduction in the efficiency and fidelity of intercellular and intracellular communication pathways that occurs with advancing chronological age. This decline impacts the ability of cells and tissues to respond effectively to hormonal cues, growth factors, and environmental stimuli, contributing significantly to the functional deterioration characteristic of senescence. The diminished responsiveness is a critical factor in the etiology of age-related diseases and the overall reduction in homeostatic capacity. This phenomenon involves changes in receptor density, post-receptor signaling cascades, and nuclear transcription factor activity.