A state of cognitive vitality characterized by maintained or improved memory, focus, and processing speed, despite chronological aging. This phrase clinically describes a brain that exhibits robust neuroplasticity and minimal signs of age-related structural or functional degradation. It reflects successful intervention against typical neuroendocrine and metabolic aging pathways. Achieving this state is a key objective in longevity medicine.
Origin
This concept is rooted in the burgeoning field of longevity medicine and neuroendocrinology, which challenges the inevitability of cognitive decline with age. The term synthesizes the physiological goals of anti-aging research with the functional outcome of preserved mental capability. It emphasizes the direct link between hormonal balance and sustained neurological health.
Mechanism
Achieving this state relies on sustaining optimal cerebral circulation and mitigating chronic neuroinflammation, which are key drivers of cognitive aging. Endogenous hormones, such as DHEA and growth factors, play a crucial role in supporting synaptic integrity and myelin sheath maintenance. The mechanism is fundamentally about maintaining the brain’s metabolic and structural resilience over time.
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