The clinical and biological process of slowing the rate at which detrimental, age-related physiological changes accumulate within the body’s systems. This is distinct from simply halting aging, focusing instead on optimizing biological function to minimize the decline typically associated with chronological age. It represents a measurable reduction in the pace of biological aging markers, often assessed through epigenetic clocks and telomere length. Achieving age deceleration is a core objective in longevity medicine and hormonal optimization protocols.
Origin
This term originates from the convergence of gerontology and preventative medicine, gaining traction within the anti-aging and longevity research communities. The concept extends beyond merely increasing lifespan to actively improving healthspan, the duration of life spent in good health. It reflects a paradigm shift from treating age-related disease to proactively managing the aging process itself.
Mechanism
Deceleration is achieved by modulating key biological pathways implicated in aging, such as nutrient sensing, cellular senescence, and mitochondrial dysfunction. Hormonal interventions, like optimizing levels of growth hormone or sex steroids, influence cellular repair and anabolic processes. Lifestyle modifications and targeted pharmacological agents are utilized to maintain genomic stability and enhance proteostasis, effectively reducing the systemic biological stress that drives aging.
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