What is the Origin of Age Associated Secretory Phenotype?

This concept emerged from cellular senescence research in the field of gerontology and molecular biology. The term synthesizes the observation of cell aging (senescence) with its subsequent biochemical behavior (secretory phenotype). Its application in hormonal health highlights the systemic impact of cellular dysfunction on endocrine signaling pathways.

What is the Mechanism of Age Associated Secretory Phenotype?

Senescent cells accumulate over time and become metabolically active without proliferating. These cells resist apoptosis and begin to secrete the SASP factors. These secreted molecules, including interleukins and matrix metalloproteinases, propagate senescence to neighboring healthy cells and induce chronic systemic inflammation. This inflammatory milieu directly impairs the sensitivity and production of key hormones, accelerating age-related hormonal decline.

Age Associated Secretory Phenotype ∞ Area

Age Associated Secretory Phenotype

Meaning

The Age Associated Secretory Phenotype, or SASP, describes the functional shift in senescent cells that leads to the secretion of a diverse array of pro-inflammatory cytokines, chemokines, growth factors, and proteases. This altered biochemical output fundamentally changes the local tissue microenvironment. This persistent, low-grade inflammatory state is a key driver of aging and age-related decline across multiple physiological systems. Understanding this phenotype is critical for interventions targeting longevity and hormonal balance.