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Age Associated Endocrine Drift

Meaning

Age associated endocrine drift refers to the inevitable, gradual, and complex shifts in the secretion, metabolism, and action of various hormones that occur as a natural consequence of advancing chronological age. This physiological process is characterized by a progressive decline in the amplitude and frequency of hormone pulses and an altered responsiveness of peripheral target tissues. Key examples include the somatopause, the decline in growth hormone and IGF-1, and the andropause or menopause-related changes in sex steroids. Understanding this drift is essential for developing proactive strategies to maintain healthspan and functional capacity in later life.