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Age-Associated Downregulation

Meaning

Age-Associated Downregulation clinically describes the gradual, inevitable decline in the activity or expression of specific biological processes, pathways, or cellular components that occurs as an organism ages. It represents a pervasive biological phenomenon where the body’s systems, including the endocrine axis, exhibit reduced responsiveness and synthetic capacity over time. This downregulation often manifests as lower circulating hormone levels, diminished receptor sensitivity, or a decreased rate of cellular repair and regeneration, directly impacting overall vitality and homeostatic resilience.