A proactive, clinical strategy focused on slowing the progressive functional and structural deterioration of physiological systems that naturally occurs with chronological aging. This approach involves targeted interventions aimed at preserving cognitive function, maintaining muscle mass, and sustaining endocrine vitality. The primary objective is to extend healthspan, ensuring a longer period of high-quality life and functional independence.
Origin
The concept arises from the intersection of gerontology, anti-aging medicine, and preventive endocrinology, moving away from merely treating age-related diseases. Its foundation is the scientific understanding of primary aging hallmarks, such as cellular senescence, telomere attrition, and mitochondrial dysfunction. Mitigation efforts are rooted in translational research seeking to apply basic biological insights to clinical practice.
Mechanism
Mitigation operates by addressing the molecular and cellular drivers of aging through pharmacological, nutritional, and lifestyle protocols. Mechanisms often include activating longevity pathways like sirtuins or AMPK, optimizing hormonal milieu to combat somatopause and andropause, and reducing chronic low-grade systemic inflammation. By bolstering cellular resilience and regenerative capacity, the rate of physiological decline is systematically reduced.
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