These are interventions aimed at modulating fundamental aging pathways to extend the period of human healthspan, often involving cutting-edge pharmacological or biological agents targeting cellular senescence or metabolic dysregulation. They represent a forward-looking approach beyond standard disease management. Such therapeutics seek to optimize physiological resilience against age-related decline.
Origin
The term combines “Advanced,” signifying deployment of novel, often non-traditional, medical science, with “Longevity Therapeutics,” rooted in the biological study of aging (geroscience) and the application of treatments to slow or reverse deleterious hallmarks of aging. Its modern context arises from breakthroughs in understanding molecular mechanisms of lifespan regulation.
Mechanism
Operationally, these agents might enhance mitochondrial function, support DNA repair mechanisms, or modulate endocrine axes to maintain homeostasis characteristic of younger physiological states. A precise mechanism often involves targeted receptor binding or pathway modulation relevant to endocrinology. For instance, some may influence sirtuin activity or mTOR signaling to promote cellular upkeep and reduce accumulated damage.
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