Clinical strategies and interventions focused on modulating core biological aging pathways to extend healthspan and lifespan. These methods often target cellular senescence, mitochondrial dysfunction, and epigenetic alterations, moving beyond simple symptom management. The goal is to optimize physiological reserve and slow the rate of age-related decline at a systemic level.
Origin
The concept stems from the convergence of gerontology, endocrinology, and precision medicine, gaining prominence as scientific understanding of the “Hallmarks of Aging” deepened in the 21st century. The term signifies a crucial shift from reactive medicine to proactive, mechanism-based health optimization.
Mechanism
They operate by influencing key endocrine axes and cellular processes, such as upregulating sirtuin activity, optimizing NAD+ levels, or precisely managing growth hormone and insulin signaling pathways. These interventions aim to restore cellular homeostasis and enhance the body’s intrinsic repair mechanisms, which often diminish with age.
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