A clinical objective focused on extending the healthspan, defined as the period of life spent in optimal physiological and cognitive function, rather than merely extending chronological lifespan. This pursuit requires targeted intervention in the fundamental pathways driving cellular aging and functional decline. It represents a proactive stance toward biological maintenance.
Origin
Emerges from the intersection of gerontology and endocrinology, specifically addressing molecular mechanisms like telomere attrition and cellular senescence that impact systemic vitality. The term implies management strategies that target the root causes of age-related endocrine system degradation. This framework prioritizes quality of life duration.
Mechanism
Interventions target core drivers of aging, such as optimizing mitochondrial function, managing nutrient sensing pathways like mTOR, and supporting DNA repair mechanisms. Successful orchestration leads to sustained endocrine balance and tissue integrity over time, slowing the rate of physiological decline associated with chronological aging.
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