What is the Origin of Advanced Glycation Endproducts?

The term originates from biochemistry and the study of the Maillard reaction, which describes the chemical process between amino acids and reducing sugars. In human physiology, this reaction occurs slowly over time, linking the concept of glycation to the progressive deterioration associated with biological aging. Clinical interest in AGEs escalated as their role in diabetes complications and cardiovascular risk became evident.

What is the Mechanism of Advanced Glycation Endproducts?

AGEs exert their damaging effects primarily through two pathways: by cross-linking structural proteins like collagen, which stiffens tissues and reduces their elasticity, and by binding to the Receptor for Advanced Glycation Endproducts (RAGE) on cell surfaces. This RAGE binding initiates pro-inflammatory signaling cascades and increases oxidative stress, contributing significantly to systemic inflammation and hormonal dysfunction.

Advanced Glycation Endproducts

Meaning

Advanced Glycation Endproducts, or AGEs, are harmful compounds formed when proteins or lipids become non-enzymatically glycated after exposure to sugars. These molecules accumulate in tissues throughout the body, acting as a key mechanism of cellular and tissue aging. High levels of AGEs are strongly implicated in the pathology of age-related decline and various chronic conditions, particularly those affecting vascular and endocrine health.