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Advanced Biological Aging

Meaning

Advanced Biological Aging describes a state where an individual’s calculated biological age, derived from measurable biomarkers, significantly exceeds their chronological age. This clinical discrepancy indicates an accelerated rate of physiological decline and functional impairment across multiple organ systems. The condition is characterized by premature cellular senescence and compromised homeostatic reserve, which elevates the risk for age-related endocrinopathies and chronic diseases. Clinically, identifying this advanced state is crucial for initiating targeted longevity and hormonal optimization strategies.