A comprehensive, proactive clinical approach designed to mitigate cellular aging processes, often involving optimization of endocrine function and metabolic pathways to enhance longevity and healthspan. This strategy moves beyond simple maintenance to actively target the hallmarks of senescence at a molecular level.
Origin
Derived from the intersection of gerontology and advanced endocrinology, this concept formalizes interventions aimed at reversing or slowing age-related decline in physiological systems. The term reflects a modern paradigm shift from passive aging management to active biological intervention.
Mechanism
Operationally, it involves modulating key regulatory networks such as sirtuins, mTOR signaling, and the clearance of senescent cells, often supported by precise hormonal balancing protocols. Such strategies aim to restore cellular homeostasis, thereby improving tissue responsiveness and systemic resilience against age-related pathology.
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