This clinical approach moves beyond mere symptom management to actively address the fundamental physiological drivers of senescence. It involves sophisticated diagnostic profiling to identify subtle shifts in endocrine function, cellular resilience, and metabolic efficiency. The goal is the sustained optimization of biological function across the lifespan, aiming to compress the period of morbidity at the end of life.
Origin
The term derives from the convergence of gerontology and precision endocrinology, representing an evolution from conventional age-related care. It acknowledges that aging is a modifiable physiological process, not merely an inevitable decline. This framework integrates concepts from longevity science and clinical application.
Mechanism
Operationally, it focuses on modulating key longevity pathways, such as mTOR signaling and sirtuin activity, often through targeted nutritional, hormonal, or pharmaceutical modulation. Interventions aim to restore youthful endocrine patterns, for instance, optimizing growth hormone axis function or improving insulin sensitivity. Such actions seek to reverse molecular damage accumulation, thereby influencing the speed of biological aging.
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