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Adult-Onset Hypogonadism

Meaning

This clinical condition refers to a deficiency in gonadal function that develops later in life, typically manifesting as insufficient production of sex hormones, such as testosterone in men, and sometimes impaired sperm or egg production. The diagnosis is generally established through a combination of clinical symptoms, which may include decreased libido, fatigue, and mood changes, alongside biochemical confirmation of low circulating hormone levels. It represents a significant endocrine disruption affecting overall metabolic health and quality of life in the aging adult.