What is the Origin of Adult Neurogenesis Stimulation?

The term combines "adult neurogenesis," the discovery that new neurons are generated throughout life, with "stimulation," indicating an intentional effort to enhance this natural process. Historically, the adult brain was considered a fixed structure, but research over the past few decades established the plasticity of certain brain regions. The clinical interest originates from understanding that enhancing neurogenesis could counteract age-related cognitive decline and neuronal loss.

What is the Mechanism of Adult Neurogenesis Stimulation?

Stimulation involves activating quiescent neural stem cells and progenitor cells within the subgranular zone of the hippocampal dentate gyrus. Key molecular pathways, often modulated by hormones like cortisol, estrogen, and thyroid hormones, influence the proliferation, differentiation, and survival of these nascent neurons. Exercise, environmental enrichment, and certain pharmacological agents can serve as physiological and exogenous stimuli by modulating these intricate signaling cascades.

Adult Neurogenesis Stimulation ∞ Area

Adult Neurogenesis Stimulation

Meaning

Adult neurogenesis stimulation is the biological process of actively promoting the creation of new functional neurons from neural stem cells within the adult brain. This phenomenon primarily occurs in the hippocampus, a region critical for learning and memory, and is influenced by systemic factors. Clinically, strategies targeting this stimulation are being explored for potential therapeutic benefits in mood disorders and neurodegenerative conditions. The regulation of this process is intrinsically linked to various endocrine and metabolic signals.