What is the Origin of Adult Neurogenesis Pathways?

The term combines 'adult,' indicating post-developmental life, with 'neurogenesis,' derived from the Greek words neuron (nerve) and genesis (creation). The concept evolved from groundbreaking research that overturned the long-held dogma that the adult mammalian brain was incapable of generating new neurons. Within the hormonal health space, its clinical relevance stems from the potent influence of sex steroids and glucocorticoids on hippocampal progenitor cells.

What is the Mechanism of Adult Neurogenesis Pathways?

Hormonal signaling, particularly from neurosteroids like DHEA and estrogen, directly modulates the proliferation, differentiation, and survival of neural progenitor cells in the subgranular zone. Key neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF), act as critical mediators, promoting synaptic integration of the newly formed neurons. This mechanism is intricately regulated by the hypothalamic-pituitary-adrenal (HPA) axis, demonstrating a clear endocrine link to brain health and stress resilience.

Adult Neurogenesis Pathways ∞ Area

Adult Neurogenesis Pathways

Meaning

The complex biological processes responsible for the creation of new functional neurons from neural stem cells in specific regions of the adult brain, primarily the hippocampus. This ongoing cellular renewal is fundamentally linked to cognitive function, mood regulation, and the brain’s capacity for plasticity throughout the lifespan. Declines in these pathways are often associated with age-related cognitive shifts and certain endocrine imbalances.