What is the Origin of Adult Hypothalamic Neurogenesis?

The term combines "Adult," referring to the post-developmental stage; "Hypothalamic," indicating the specific brain region responsible for neuroendocrine control; and "Neurogenesis," derived from Greek neuron (nerve) and genesis (creation). It belongs to the domain of neuroscience and endocrinology, emphasizing the brain's role in systemic hormonal regulation.

What is the Mechanism of Adult Hypothalamic Neurogenesis?

Neural stem and progenitor cells residing in specific hypothalamic niches, such as the median eminence, differentiate into mature neurons. These newly formed neurons integrate into existing neural circuits to potentially modulate the release of neuropeptides and hormones. This mechanism is influenced by metabolic signals, such as leptin and ghrelin, suggesting a dynamic interplay between peripheral energy status and central nervous system structure.

Adult Hypothalamic Neurogenesis ∞ Area

Adult Hypothalamic Neurogenesis

Meaning

The process of generating new neurons (neurogenesis) within the hypothalamus of the adult brain. This region is critical for regulating fundamental homeostatic functions, including hormonal balance, metabolism, appetite, and body temperature. Understanding this process is vital for comprehending neural plasticity and its potential role in endocrine health and metabolic disorders.