What is the Origin of Adult Hippocampal Neurogenesis Enhancement?

The concept combines "Adult Neurogenesis," the discovery that new neurons can be born in the adult brain, with "Hippocampal," referencing the brain region critical for memory and emotion, from the Greek hippokampos (sea-horse). "Enhancement" denotes the clinical goal of maximizing this natural biological process through various interventions.

What is the Mechanism of Adult Hippocampal Neurogenesis Enhancement?

Various systemic and hormonal factors, including brain-derived neurotrophic factor (BDNF), certain sex steroids, and growth hormone, modulate the proliferation and survival of neural progenitor cells. These factors activate intracellular pathways, such as the CREB signaling cascade, which drive the differentiation of stem cells into mature, integrated neurons. Lifestyle interventions, including targeted exercise and dietary modifications, are recognized as potent modulators of this pathway.

Adult Hippocampal Neurogenesis Enhancement ∞ Area

Adult Hippocampal Neurogenesis Enhancement

Meaning

This term refers to the clinical and physiological process of increasing the rate at which new functional neurons are generated from neural stem cells within the dentate gyrus of the adult hippocampus. Enhancement of this process is directly linked to improvements in specific cognitive functions, including learning, mood regulation, and memory consolidation. Optimizing this endogenous brain plasticity is a key focus in neurological and hormonal wellness strategies.